ACHR

Objective To explore the expression of α 3 subunit mRNA of acetylcholine receptors ( AChR) in human lymphoid tissue and the effect of the neuroendocrine parasympathetic system on the immune system.

目的探讨人淋巴组织中乙酰胆碱受体α3（AChRα3）亚基mRNA的表达及副交感神经系统对免疫系统作用的物质基础。

CONCLUSION The human anti-AChR antibodies, secreted from the mice transgenic for human Ig loci, induced with Torpedo AChR, are able to bind to AChR in the mouse muscles, which leads to the damages of AChR, resulting in the animal EAMG.

[结论]电鳐乙酰胆碱受体刺激人免疫球蛋白转基因小鼠产生的人抗乙酰胆碱受体抗体，可与肌肉组织中的乙酰胆碱受体结合，导致肌肉收缩无力，可诱导重症肌无力。

Specific T cell mediated immunity against AChR in peripheral blood monocytes in patients with myasthenia gravis expression of sIL 2R, IFN γ and IL 4 and transcription of their mRNA

重症肌无力患者外周血乙酰胆碱受体特异性T细胞sIL-2R、IFN-γ、IL-4的表达和转录

The downregulation of specific T Lymphocyte responses by nasal administration of AChR in EAMG rats

鼻腔AChR耐受低调EAMG大鼠特异性T淋巴细胞反应

AChR subunit mRNA expression in human muscles of patients with myasthenia gravis

重症肌无力患者肌肉AChR亚单位基因的表达

Conclusion: Although production of myosin-reactive Abs is not prerequisite for induction of MG, for myosin cross-reacts with AChR, myosin-Ab may play an important role in the pathogenesis of MG.

结论：Myosin-Ab虽然不是诱发MG的必要条件，但由于myosin与AChR存在抗原交叉性，myosin-Ab在MG的发病机制中可能起重要作用。

Construction and Screening of TsF cDNA Library Specific for AchR

AchR特异性TsF cDNA文库的构建及筛选

Objective: To analyze the interactions between AChR γ subunit gene and nuclear factors present in developing chicken skeletal muscle.

目的：分析鸡乙酰胆碱受体（acetylcholinereceptors，AChR）γ亚基基因与不同发育阶段鸡骨骼肌核因子的相互作用。

Difference of T cell immune response to AChR in Lewis rats and Wistar Furth rats

Lewis和Wistar Furth大鼠T细胞对AChR的免疫应答不同

And could the activated TDCs present antigen AChR especially in MG thymus?

活化TDC能否提呈MG特异性抗原-胸腺组织中AChR蛋白？

Results The length of postsynaptic membrane decreased obviously. The ratio of the length of postsynaptic with presynaptic membrane, and that the motor nerve terminal area with postsynaptic membrane area diminished. The AChR on the postsynaptic membrane decreased by 35.9 percent as well.

结果MG时突触后膜长度缩短，后、前膜长度比值变小，神经末端面积及其与突触后膜面积之比变小，突触后膜上的乙酰胆碱受体（AChR）减少了35.9%。

Objective To observe the time profile of the changes of mRNA of γ and ε subunit of acetylcholine receptor ( AChR) in skeletal muscle and the level of calcitonin gene related peptide ( CGRP) in spinal motoneuron after upper motoneuron injury.

目的观察大鼠上运动神经元损伤后，骨骼肌乙酰胆碱受体γ亚单位和ε亚单位mRNA的变化以及脊髓前角降钙素基因相关肽的变化。

Wet weight of triceps surae was measured. The denervated muscle was given HE staining and Mallory staining, while the frozen muscle biopsy tissue was given Immunofluorescence with postsynaptic membrane AchR specific antibody.

测量小腿三头肌肌湿重，并分别应用HE染色、Mallory三色染色的方法对失神经肌肉组织进行染色，同时应用突触后膜乙酰胆碱受体（AchR）特异性抗体对肌肉冰冻切片进行免疫荧光染色。