Chemotherapy agents

Michael Reed, MD, and his UC colleagues found that "turning off" the RB pathway in lung cancer cells resulted in an altered response to chemotherapy agents and more cancer cell death.

辛辛那提大学医学博士Michael Reed和他的同事发现，关闭肺癌细胞的RB通路会导致该细胞对化疗药物的反应发生改变以及更多癌细胞的死亡。

Conclusion The main cost spent during the chemotherapy was on the agents given. The total cost could be reduced by outpatient therapy.

结论白血病治疗的主要费用是药费，在门急诊治疗可降低治疗费用；

Objective: Observation of clinical curative effect and side effect for newly diagnosed and recurrent acute leukemia ( AL) using mitoxantrone ( MTZ) and other chemotherapy agents.

目的：观察米托蒽醌（MTZ）治疗初治、复发急性白血病（AL）的临床疗效和毒副作用。

Since most chemotherapy agents such as paclitaxel induced autophagic protection in tumor cells, which in turn weakened its anti-tumor effect. Moreover hormone-independent PCa cells showed more potential to anti-apoptosis.

由于大多数化疗药物如紫杉醇等可引起肿瘤细胞产生自噬性保护机制，削弱其抗肿瘤效果，而且激素非依赖性前列腺癌细胞比激素依赖性细胞抗凋亡能力强，对药物敏感性差。

Observation of clinical curative effect for acute leukemia using mitoxantrone and other chemotherapy agents

米托蒽醌联合用药治疗成人急性白血病临床观察

About 70 percent of patients have local or distant metastases before they seek medical attention. Although new chemotherapy agents and advanced operation are discovered, the five-year survival rate of patients with an advanced disease is still nearly 30% during the last decade.

据统计，约70%的卵巢癌病人在就诊时已有局部或远处的转移灶，近十几年来，虽然手术和化疗的治疗方案有所改进，但晚期患者的5年生存率仍低于30%。

However, lung cancer cells usually acquire resistance to current standard chemotherapy based on platinum agents, leading to a poor curative effect.

然而，肺癌对以铂类为基础的经典化疗方案容易产生耐药，导致化疗效果不佳。

We discuss bladder preserving approaches, combination chemotherapy including new agents, targeted therapies, and advances in molecular biology.

在该文中我们讨论了通过采用新药、靶向治疗及分子生物学新技术等进行联合化疗来保留膀胱功能。

Conclusion: Induced HB cell apoptosis may be an important mechanism of chemotherapy agents.

结论：诱导HB细胞凋亡可能是化疗药物杀死瘤细胞的重要作用机制；

Changes of radiotherapy sensitivity of cells treated by chemotherapy agents were analyzed by colony formation experiment.

应用集落形成实验分析化疗药物作用后细胞放射敏感性的变化。

ADM-PLGA-NPs are expected to become a new targeting chemotherapy agents.

ADM-PLGA-NP有望成为一种新型的药物化疗制剂。

In cancer cells, NRF2 activity runs amok, sweeping away all cellular toxins, including chemotherapy agents.

在癌细胞上，NRF2活性疯狂增强，细胞内的毒素包括化疗药物被彻底清除。

Pae in low concentration had synergetic effect in inhibiting the proliferation of HT-29 cells with several chemotherapy agents.

低浓度的Pae与化疗药物协同可产生较强的抑制细胞增殖作用。

Pae had synergetic antitumor effect with cell cycle specific chemotherapy agents. Pae could induce apoptosis of HT-29 cells. The possible mechanism is the influence in distribution of cancer cell cycle, down-regulation the ratio of bcl-2/ bax and the expression of p53 protein.

Pae能诱导HT-29细胞凋亡，其作用机制可能与影响癌细胞的细胞周期、下调bcl-2/bax的比例及p53蛋白的表达有关。

The resistance of avian influenza virus to chemotherapy agents ( ion channel inhibitor and neuraminidase inhibitor) often influences the disease control effect.

由于禽流感病毒对离子通道抑制剂、神经氨酸酶抑制剂等化学药物容易产生抗性，这将都会影响疾病的控制效果。

Gefitinib has a more favorable tolerability profile and less adverse effect than traditional chemotherapy agents in the treatment of tumor since it aim directly at tumour cells.

与传统化疗药物相比，吉非替尼具有瞄准特定的分子靶点、不良反应小和特异性强等优点。

The difficulty to cure cancer with chemotherapy agents is a well-recognized problem. One way to enhance the effect of anti-cancer drugs is to use them in combination.

恶性肿瘤的治疗是一个世界性的难题，联合用药是提高肿瘤治疗效果的途径之一。

Nursing on cancer patients with diabetes treated by chemotherapy regimen including taxanes agents

糖尿病癌症患者用紫杉类方案化疗时的血糖控制及护理

Twelve cases received adjuvant chemotherapy of platinum agents, but recurrence or metastasis was found in8 of them several months after surgery.

术后12例行铂类辅助化疗，但8例在手术后数月内发生复发或转移，中位生存期为19个月。

Methods: In cultivated cells, 50% of inhibitory concentrations ( IC_ ( 50)) of chemotherapy agents were detected singly or combined with AdI κ B α transfer. Annexin-V/ PI stain and caspase 3 activity were measured to detect the apoptosis caused by treatment.

方法（1）检测50%抑制浓度（IC50）以确定化疗单用或联合AdIκBα对H460细胞增殖的影响，同时采用Annexin-V/PI染色法和caspase3活性测定来检测治疗引起的细胞凋亡情况；

The study evaluating combinations of different molecular targeted agents and molecular targeted agents combined with cytokine or chemotherapy agents are ongoing.

分子靶向药物联合应用及与细胞因子或传统化疗药物的联合应用正在研究中。

Chemotherapy plays a pivotal role in the treatment of osteosarcoma. Currently, the main chemotherapy agents for osteosarcoma comprise cisplatin, doxorubicin, ifosfamide and high dose of methotrexate.

化疗在骨肉瘤治疗中的地位举足轻重，当前普遍使用的化疗药物有顺铂、阿霉素、异环磷酰胺及大剂量的甲氨蝶呤。