Cyclosporine

The influence of azathioprine on the pharmacokinetics of cyclosporine A in rabbits

硫唑嘌呤对环孢素A家兔药动学的影响

Aim To monitor the whole blood trough concentration of cyclosporine A ( CsA) in renal transplant recipients, and to suggest optimal therapeutic window of CsA.

目的通过监测肾移植后病人环孢素A（CsA）全血浓度，提出CsA在三联免疫抑制用药方案中的理想治疗窗。

The drug cyclosporine is a widely used immunosuppressive agent among transplant recipients.

药物环孢素是一种广泛使用的免疫抑制剂之间的移植受者。

Heart-thymus combined transplantation in thymectomized rats led to an evident survival time of ( 14.13 ± 5.82) d ( P < 0.01) for cardiac graft, which further obtained long term survival after short course of treatment with cyclosporine.

胸腺切除后行心胸腺联合移植可明显延长移植心的存活达（14.13±5.82）d（P

Conclusion: Low dose cyclosporine is effective in treatment of severe refractory ulcerative colitis failed to response to steroids therapy, low dose is helpful to assure efficacy and to decrease adverse drug reactions.

结论：环孢素对激素治疗无效的重度溃疡性结肠炎患者治疗有效，低剂量有助于在保证效果的情况下减少严重不良反应发生。

OBJECTIVE To study the relationship between C-reactive protein ( CRP ) and ( tubulointerstitial ) ( fibrosis ) ( TIF ) in a model of chronic cyclosporine ( CsA ) nephrotoxicity.

[目的]探讨C反应蛋白 ( CRP ) 与慢性环孢素A ( CsA ) 肾毒性肾小管间质纤维化的关系.

Cyclosporine, mycophenolate mofetil and anti CD25 antibody were used for GVHD prevention.

用环胞菌素A、霉酚酸酯、鼠抗人CD25单克隆抗体作为移植物抗宿主病（GVHD）预防方案；

Csa group : 25 mg · kg-1 cyclosporine A was fed everyday.

环孢素组( Csa )给予环孢素25mg.kg-1.d-1.

CYCLOSPORINE A-Drug marketed with trade names Sandimmune and Neoral.

环孢霉素A——一种商品名为SandimmuneandNeoral的药物.

Methods: cyclosporine A blood concentration in 51 cases of renal transplantation recipients were measured by means of fluorescence polarization immunoassay ( FPIA), and the first monitoring time of CsA blood concentration, CsA blood concentration, the influence of monitoring rule were analyzed.

方法采用荧光偏振免疫分析法（FPIA法）测定51例患者术后CsA谷浓度，并对其首次CsA谷浓度监测时间、CsA谷浓度及监测规律性的影响进行统计分析。

Objective To evaluate the safety and reliability of cyclosporine microemulsion ( CsA-ME) C_2 monitoring and to determine the target level of C_2 in Chinese adult liver transplant recipients.

目的评估微乳化环孢素A（CsA ME）服用2h后药物浓度（C2）监测的安全性和可靠性，初步确定适合中国成人肝移植受体的C2目标浓度。

Objective To analyze the causes and outcome of conversion from tacrolimus ( FK506) to cyclosporine-A ( CsA) in recipients after liver transplantation.

目的分析肝移植后需用环孢素A（CsA）替换他克莫司（FK506）的原因和结果。

Monitoring of Peak Blood Concentration in Renal Transplant Recipients 2h after Oral Administration of Cyclosporine A and Study on Therapeutic Window Concentration

肾移植术后服用环孢素A2h血药浓度峰值监测及治疗窗浓度探讨

Synergetic protective effect of testicular cells expressing Fas ligand and cyclosporine A on the survival of islet allografts

Fas配体阳性睾丸细胞和环孢素A对移植胰岛细胞存活起协同保护作用

CONCLUSION Cyclosporine A eye film is a new type eye film to be worth of developing.

结论：环孢素A缓释眼膜是一种良好的新剂型，值得开发应用。

Cyclosporine A ( CsA) is a potent immunosuppressive agent, which is widely used to prevent rejection in organ transplants and to treat autoimmune diseases by oral administration.

环孢素A是一种强效免疫抑制剂，其口服制剂广泛应用于器官移植早期免疫排斥反应的预防以及自身免疫疾病的治疗。

CyA was quantified by absorbance at 208 nm , with cyclosporine D as internal standard.

采用环孢菌素D为内标,在208nm处紫外定量检测.

Successive Assessment of Internal Quality Control for Therapeutic Drug Monitoring of Cyclosporine and Phenytoin

环孢素和苯妥因治疗药物监测内部质控的连续性评价

In chronic AA, the rate was 83.3% in treatment with cyclosporine A combined androgen and 76.9% with androgen alone.

慢性再障中单用雄激素治疗有效率76.9%，CSA和雄激素联合应用的有效率为83.3%；

OBJECTIVE : To study the effect of cyclosporine A ( CsA ) on the fluidity of erythrocyte membrane in rabbit.

目的: 研究环孢素A对家兔红细胞膜流动性的影响.

Experimental study on reversal mechanism of multidrug resistance by cyclosporine A

环孢菌素A逆转白血病多药耐药机制的实验研究

Results Cyclosporine A, azathioprine and methylprednisolone were the baseline immunosuppression management.

结果术后常规给予环孢素A、硫唑嘌呤和甲基强的松龙三联免疫抑制剂。

Anti P glycoprotein monoclonal antibody JSB 1 and cyclosporine in overcoming adriamycin resistant human bladder cancer cell line

抗P-糖蛋白单克隆抗体JSB-1和环孢素A协同逆转人膀胱癌MDR的研究

Experimental studies on drug reaction of cyclosporine A-containing microspheres after subconjunctival injection

结膜下注射环孢霉素A微粒体的药物反应性

GVHD prophylaxis regimen consisted of cyclosporine ( CsA ) and mycophenolate mofetil ( MMF ).

移植物抗宿主病(GVHD) 的预防采用环孢菌素A ( csa ) +霉酚酸酯 ( MMF ) 方案.

CONCLUSION Cyclosporine A eye film is a new film to be worth of developing.

结论:环孢素A缓释眼膜是一种良好的新剂型,值得开发应用.

Objective : To prepare cyclosporine A submicron emulsion for intravenous injection.

目的: 制备静脉注射用环孢素A亚微乳.

A clinical trial of anti-CD_4 CD_8 monoclonal antibodies combined with cyclosporine A in treatment of severe aplastic anemia

单克隆抗体CD4及CD8联合环孢素A治疗重型再生障碍性贫血临床研究

AIM : To study the effects of cyclosporine ( Cyc ) on apoptosis of HL-60 cells.

目的: 研究环孢菌素 ( Cyc ) 在 HL -60细胞凋亡中的作用.

Therapeutic drug monitoring of cyclosporine in patients with liver transplantation

肝移植术后环孢素治疗药物监测