Drug-drug interaction

Research Progress of Drug-Drug Interaction in Corpore

体内药物相互作用研究进展

The role of P-glycoprotein in absorption, distribution, metabolism, excretion and the drug-drug interaction mediated by induction and inhibition of P-glycoprotein are reviewed in this paper.

本文综述P-糖蛋白对药代动力学的作用及由P-糖蛋白的诱导和抑制所引起的药物相互作用。

Induction and inhibition of cytochrome P450 ( CYP450) catalytic activity has been concluded to be closely involved in pharmacokinetic drug-drug interaction.

细胞色素P450酶（CYP450）活性的诱导或抑制，是引起临床药物代谢性相互作用的主要作用机制。

Such an effect is referred to as a metabolic drug-drug interaction ( DDI).

这就是所谓的代谢水平的药物-药物相互作用（Drug-drug interaction，DDI）。

Induction and inhibition of cytochrome P 450 ( CYP 450 ) catalytic activity has been concluded to be pharmacokinetic drug-drug interaction.

细胞色素P450酶 ( CYP450 ) 活性的诱导或抑制,是引起临床药物代谢性相互作用的主要作用机制.

Drug-drug interaction caused by combined medication is one of the influence factors on veterinary drug residues in domestic animal breeding.

在动物养殖过程中，联合用药所产生的药物之间的相互作用是造成兽药残留的众多影响因素之一。

While the discontinuation syndrome ( 1.2%) and drug-drug interaction ( 6.3%) seldom influenced the choice of drug.

而停药综合征（1.2%）及药物之间的相互作用（6.3%）则很少影响医生的用药选择。

Monitoring VPA levels in serum of epileptic patients is desirable mainly for study its pharmacokinetics and drug-drug interaction.

人体内丙戊酸血浓度测定方法的建立对于研究其药物动力学及药物相互作用研究具有重要意义。

So one of two drugs is produced it is unable to suit like the patient with this, or there is situation of drug-drug interaction, propose considering using another drug.

因此若病人对此二药物之一产生无法适应，或有药物交互作用的情形，建议可考虑使用另一药物。