Rosuvastatin Calcium

Pharmacokinetics and bioequivalence of domestic and imported rosuvastatin calcium tablets in healthy volunteers

国产与进口瑞舒伐他汀钙片在健康人体的药代动力学及生物等效性

Results: The serum C-reactive protein, interleukin-6, tumor necrosis factor alpha and serum uric acid levels in rosuvastatin calcium groups were lower than those in the model groups ( P 0.01).

结果：瑞舒伐他汀钙高、中、低剂量组血清C反应蛋白、白细胞介素-6、肿瘤坏死因子-α及血尿酸水平均明显低于模型组（P0.01）。

The pathological results showed the damage of aortic endothelium in model group was significantly more severe than that in control group, and was dose dependent in rosuvastatin calcium groups, and it was the lightest in high dose group.

病理结果显示主动脉内皮损害模型组明显较对照组严重，瑞舒伐他汀钙高、中、低剂量组血管内皮损害有不同程度减轻，呈剂量依赖性，以高剂量组损害最轻。

The rosuvastatin calcium could significantly decrease the levels of IFN-γ in serum and the thoracoabdominal aorta and decrease the levels of resistin in serum, inhibit inflammatory and inhibit the progression of atherosclerosis.

瑞舒伐他汀钙可有效地降低动脉粥样硬化小鼠的血和主动脉中IFN-γ含量以及血清抵抗素含量，显著抑制炎症反应，抑制粥样斑块进展。

Effect of Rosuvastatin on Cardiac Function and Cytokines in Patients with Dilated Cardiomyopathy Antagonism for different doses of taurine on calcium overload in myocardial cells of diastole heart failure rat model

瑞舒伐他汀对扩张型心肌病患者心功能及细胞因子的影响牛磺酸对舒张性心力衰竭大鼠心肌细胞钙超载的拮抗作用