dna methyltransferase

BACKGROUND& OBJECTIVE: 5-Aza-2 ′-deoxycytidine ( 5-Aza-CdR) is an inhibitor of DNA methyltransferase; it may reactivate methylated antioncogene, therefore, inhibit the growth of cancer cells.

背景与目的：5-杂氮-2′-脱氧胞苷是DNA甲基转移酶抑制剂，能使因甲基化而失活的抑癌基因重新激活，进而抑制肿瘤的生长。

In this thesis, I describe the screening of several mutations in the DNA methyltransferase gene, AT1G19340.1, from the flowering plant Arabidopsis thaliana.

本试验研究拟南芥甲基转移酶基因家族中代号为At1g19340.1基因的功能，属于拟南芥功能基因组计划的一部分。

Effects of DNA methyltransferase activity in lung cancer cells treated with 5-Aza-CdR

5-Aza-CdR对肺癌A549细胞DNA甲基转移酶活性的影响

Methods To investigate the changes of DNA methyltransferase 1 ( DNMT_1) mRNA and methylation status of progesterone receptor double promotors ( PRA, PRB) before and after 5-Aza-2 ′-deoxycytidine treatment.

方法用5-杂氮-2′-脱氧胞苷处理白血病细胞株HL-60、K562和Jukat，分析处理前后DNA甲基转移酶1mRNA表达和孕酮受体双启动子（PRA、PRB）甲基化状态的变化。

This article briefly discusses plant DNA methyltransferase, the mode and the loci of Methylation and the epigenetic phenomenon originated by DNA methylation.

简要论述了植物DNA甲基转移酶、甲基化方式、发生位置及DNA甲基化所引起的表观遗传现象。

DNA methyltransferase inhibitors can inhibit tumor growth significantly, and have good therapeutic effect.

研究表明DNA甲基转移酶抑制剂可以显著抑制肿瘤生长，有很好的治疗效果。

In this process, DNA methyltransferase is indispensable.

在这个过程中，甲基转移酶起着重要的作用。

Synergistic Anticancer Effect of DNA Methyltransferase Inhibitor Combined with Thymidylate Synthase Inhibitor in vitro

DNA甲基化转移酶抑制剂与胸苷酸合成酶抑制剂体外联合用药的抗肿瘤增效作用

Progress in DNA methyltransferase inhibitors

DNA甲基转移酶抑制剂的研究进展

Effect of eukaryotic expression plasmid DNA methyltransferase gene on methylation status and transcription level of DNA mismatch repair genes in human colon cancer cell line

甲基转移酶1表达质粒对结肠癌细胞错配修复基因甲基化及其表达的影响

Identification and Characterization of the Infectious Spleen and Kidney Necrosis Virus Cytosine DNA Methyltransferase Gene

鳜鱼传染性脾肾坏死病毒的胞嘧啶5-甲基转移酶基因结构及其序列分析

Effect of duck HBV on the activity of o~ 6-methylguanine DNA methyltransferase

鸭乙肝病毒对O~6-AT酶活性作用的研究

The recent study confirmed that the level of DNA methylation in genome was not only affected by DNA methyltransferase ( DNMT), but also by other factors, such as histone modification, diet and environment and RNA interference, etc.

目前研究发现，基因组中DNA甲基化的水平不仅受DNA甲基化转移酶（DNMT）的影响，还与组蛋白甲基化、饮食与环境、RNA干扰等多种因素有关。

Pretreatment with DNA methyltransferase inhibitor 5-azacytidine suppressed SNP-induced isoflavone production.

DNA甲基转移酶抑制剂5&氮杂胞苷阻断了一氧化氮激发下异黄酮合成。

DNA methylation is catalyzed and maintained by DNA methyltransferase ( DNMT). More and more scholars pay attention to DNA methylation and propose that over-expression and/ or increased activity of DNMT is an early molecular event of carcinoma cells.

DNA甲基化是由DNA甲基转移酶（DNMT）催化发生并维持的，并认为DNMT活性增高是肿瘤细胞具有特征的早期分子改变，因而受到越来越多的学者关注。

Objective To explore the significance of DNA methyltransferase ( Dnmt) in the development of acute leukemia.

目的探讨DNA甲基转移酶（Dnmt）在急性白血病患者疾病发展中的意义。

Objective To investigate the effect of environmental contaminants on development rate and DNA methyltransferase activity of preimplantation embryos.

目的探讨环境污染物对着床前小鼠胚胎发育的直接影响，以及对基因组DNA甲基化的影响。

Caused by the methylation of gene silencing the tumor, available through DNA methyltransferase non-competitive or competitive inhibitors methylation occurs, activating the silence of the tumor suppressor gene, so as to achieve the aim of the treatment of tumors.

由甲基化引起基因沉默而出现的肿瘤，可通过DNA甲基转移酶非竞争性或竞争性抑制剂抑制甲基化的发生，活化沉默的抑癌基因，从而达到治疗肿瘤的目的。

The Expression of DNA Methyltransferase 1 and CD11a Genes in Systemic Lupus Erythematosus Patients

DNA甲基转移酶1和CD11a基因在SLE患者中的表达

The development rate and DNA methyltransferase activity were determined.

观察1细胞期胚发育至胚泡期胚的发育率；测定胚泡期胚的DNA甲基转移酶（DNA methyltransferase）活性。

Impacts of the transfection of antisense DNA methyltransferase ⅰ gene fragment into hepatocellular cell on its sensitivity to tumor necrosis factor related apoptosis inducing ligand

反义甲基转移酶基因片段增强肿瘤坏死因子相关凋亡诱导对肝癌细胞的作用

Isolation and Expression Analysis of DNA Methyltransferase Genes in Strawberry and Apple

草莓和苹果DNA甲基转移酶基因分离及表达分析

Expression of O~ 6-Methylguanine-DNA Methyltransferase in breast cancer

乳腺癌组织中O~6-甲基鸟嘌呤-DNA甲基转移酶的表达

The expression of DNA methyltransferase, demethylase and tumor-associated genes in human gastric cancer

人胃癌组织DNA甲基化酶、去甲基化酶与肿瘤相关基因的表达

Objective To investigate the relationship of the expression of DNA methyltransferase, demethylase ( mbd2) and tumor-associated genes in human gastric cancer.

目的探讨胃癌组织中甲基化酶、去甲基化酶基因与肿瘤相关癌基因和抑癌基因的关系。

To test whether DNA methylation plays a role in somaclonal variation, the calli were treated with 5-azacytidine that reduces cytosine methylation by blocking activity of DNA methyltransferase.

为了检测DNA甲基化在体细胞克隆多样性中的作用，愈伤组织用5-氮胞苷进行处理，5-氮胞苷通过抑制DNA甲基转移酶的活性降低胞嘧啶的甲基化水平。

To observe the change of DNA methyltransferase ( Dnmt) in osteosarcoma cell lines differentiation induction in vitro, so as to explore the function and relativity of Dnmt in malignant osteosarcoma cell during differentiation induction in vitro.

目的观察骨肉瘤细胞MG-63在体外诱导逆转过程中DNA甲基转移酶（DNA methyltransferase，Dnmt）的变化，探讨Dnmt与骨肉瘤恶性逆转的相关性及其作用。

The re-expression of p15~ ( INK4B) gene in leukemia cells induced by in vitro DNA methyltransferase and histone deacetylase inhibition

体外试验诱导白血病细胞p15~（INK4B）基因重新表达

Objective To investigate the activity and mRNA expression of DNA methyltransferase ( DNMT) in gliomas and the effects of chemotherapy and radiotherapy on them.

目的了解DNA甲基转移酶在星形细胞瘤中的活性和DNMTmRNA表达水平及放、化疗对它的影响。

The co-effect of extracellular-signal regulated kinase mitogen-activated protein kinase signaling pathway inhibitor and DNA methyltransferase inhibitor on human colon cancer cells

丝裂原激活蛋白激酶阻断剂与DNA甲基化酶抑制剂对人结肠癌细胞的协同影响