epigenetic

This study was designed to improve the level of acetylation by knock down the expression of histone deacetylase expression with RNA interference technology. A possible mechanism was provided for improving epigenetic modifications and exploring the early development of mammalian embryos. 1.

本研究运用RNA干扰技术对小鼠HDAC2进行了干扰，通过抑制组蛋白去乙酰化酶的表达提高乙酰化修饰水平，以探索表观遗传修饰影响哺乳动物胚胎早期发育的可能机制。

Increasingly, biologists are finding that non-genetic variation acquired during the life of an organism can sometimes be passed on to offspring& a phenomenon known as epigenetic inheritance.

越来越多的生物学家发现了一个被称为表观遗传的现象&生物有机体后天获得的非遗传变异有时可以被遗传下去。

Epigenetic changes have been found in tumors and some autoimmune diseases.

肿瘤及多种自身免疫性疾病都有表观遗传学的改变.

Proliferating cell nuclear antigen ( PCNA) is a growth-regulated protein which coordinates events in DNA replication, DNA repair, cell cycle control and epigenetic inheritance. PCNA gene is regulated at both transcriptional and post-transcriptional levels.

增殖细胞核抗原（proliferating cell nuclear antigen，PCNA，PCNA）是一种生长调控蛋白，在DNA复制、修复、细胞周期调控、基因外遗传（epigenetic inheritance）等事件的协同机制中发挥重要功能。

The discovery of an epigenetic component to PAH may offer new therapeutic targets.

PAH后生调控成分的发现可能成为新的治疗靶点.

The paper introduces polluted irritation of industrial and urban wastewater and its effect of minimization, resource, then the epigenetic pollution control and prevention countermeasures are proposed.

该文介绍了工业和城市废水污灌，使其减量化、资源化的作用与效果，论述了后生污染控制及防治对策。

Several epigenetic drugs targeting DNA methylation and histone deacetylation enzymes have been tested in clinical trials.

靶向DNA甲基化和组蛋白去乙酰化酶的几个表观药物已经在临床试验中被测试。

This article briefly discusses plant DNA methyltransferase, the mode and the loci of Methylation and the epigenetic phenomenon originated by DNA methylation.

简要论述了植物DNA甲基转移酶、甲基化方式、发生位置及DNA甲基化所引起的表观遗传现象。

These potential epigenetic control factors may be the potential key targets to correct tumors in future.

而这些表观遗传学调控因子在未来可能成为治疗肿瘤的潜在靶点。

DNA methylation is an important epigenetic modification which regulates a number of biological processes.

DNA甲基化作为一种重要的表观遗传修饰,调节着机体许多生物学过程.

The Mississippi Valley-type ( MVT ) lead-zinc deposits are the classic epigenetic hydrothermal ores.

密西西比河谷型矿床为后生热液矿床.

Biologists have suspected for years that some kind of epigenetic inheritance occurs at the cellular level.

生物学家很多年来一直怀疑一些表观遗传发生在细胞水平上.

Core processes of epigenetic inheritance include DNA methylation, histone modification, nucleosome remodeling, nuclear dynamics and chromatin interaction with non-coding RNAs.

核心过程的表观遗传的产业包括DNA甲基化、组蛋白改性、核小体重建、核染色质动力学和互动子都存在。

These long ncRNAs appear to be functioning as an endogenous RNA regulatory system, playing a major role in the epigenetic control of differentiation and development.

这些长期的非编码RNA作为内源性RNA的规管制度的运作，扮演一个主要角色的分化和发育的表观遗传控制。

At the molecular level, cellular plasticity and dynamics are governed by genetic and epigenetic regulations.

在分子水平, 细胞可塑性与动力学特征受遗传学及表观遗传学的调控.

Epigenetic modification related to somatic nuclear transfer Study on the change of T lymphocyte and natural kill cell in Wilson's disease

体细胞核移植诱导的表观遗传学变化肝豆状核变性T淋巴细胞亚群及NK细胞的变化

Methylation of cytosine bases in DNA provides a layer of epigenetic control in many eukaryotes that has important implications for normal biology and disease.

DNA中胞嘧啶碱基的甲基化在很多真核细胞中提供了一层表观控制，它对于正常生物学和疾病有着重要的意义。

Epigenetic is the latest biological science in recent years, which mainly researches gene function reversible and heritable variation without DNA sequence changes.

表观遗传学是近年来新兴起的生物学学科，主要研究在没有DNA序列改变情况下基因功能可逆的、可遗传的变异。

The most striking finding was the presence of epigenetic changes meaning that the DNA is altered and this alteration lasts for long periods.

最引人注目的发现是意味着DNA改变的表观遗传学变化的存在，而且这种改变会持续很长一段时间。

This gene regulation is accomplished by epigenetic processes that control gene expression without altering DNA.

这是基因调控是由控制基因的表观遗传完成的，并没有改变DNA。

Epigenetic modifications are often retained when cells divide, and can sometimes be passed on to offspring.

表观遗传修饰经常在细胞分裂的时候会保留下来, 并且有时会传递给后代.

It includes epigenetic uranium impregnations in sandstone.

它意味着外生的铀进入到沙岩中.

The Epigenetic Pathogenesis of Systemic Lupus Erythematosus

系统性红斑狼疮（SLE）的表观遗传学发病机制研究进展

There are several types of epigenetic inheritance systems methylation of DNA, RNA interference, histone acetylation and protein modification.

目前发现有如下几种表观遗传分子机制：DNA甲基化，RNA干扰，组蛋白乙酰化和组蛋白修饰。

The study found that children exposed in the womb to maternal smoking had differences in DNA methylation, an epigenetic mechanism in which small chemical compounds are added to DNA.

研究发现，母亲孕期吸烟，孩子在DNA甲基化上表现出差异，DNA甲基化是一种表观遗传学机制，在这个过程中化学小分子添加到DNA上。

Our study implicates modification of the neuronal DNA methylome as a previously underappreciated mechanism for activity-dependent epigenetic regulation in the adult nervous system.

这些研究表明神经激活介导的DNA甲基化状态改变由可能是成体神经系统中一种重要的表观遗传学调控机制。

There are four known mechanisms for epigenetic inheritance.

现有四种已知的机理可以说明表观遗传.

The discovery of enzymes that reverse histone methylation challenges the current understanding that histone methylation is a stable epigenetic marker and provides a novel way to study histone modifications.

既往认为组蛋白甲基化是稳定的表观遗传标记，而组蛋白去甲基化酶的发现对这一观点提出了挑战，也为进一步深入研究组蛋白修饰提供新的途径。

Epigenetic modifications, such DNA methylation, have also been implicated in many cancers but have yet to be examined in the East Asian population of colorectal cancer patients.

同时，表观遗传学修饰，如DNA甲基化，被认为在许多种恶性肿瘤中广泛存在。而亚洲大肠癌患者的甲基化状态仍有待进一步研究。

Gene silencing is a kind of epigenetic phenomenon discovered in transgenic plants in recent years.

摘要基因沉默是近几年来在转基因植物中发现的一种后生遗传现象.