histone

Histone deacetylase ( HDAC) greatly affects the chromatin topology and gene expression, and HDAC can be a new strategy in human cancer or tumour therapy.

组蛋白去乙酰化酶（HDAC）对染色质分布和基因调节起着重要的作用，也是治疗癌症和其它疾病的新靶点。

The level of his-tone acetylation is determined by the activities of histone acetyltransferases and histone deacetylases.

组蛋白乙酰转移酶和组蛋白去乙酰酶活性共同决定了组蛋白的乙酰化水平.

Histone deacetylases are enzymes ( HDACs) that can regulate the activity of transcription factors and affect bone development.

组蛋白去乙酰化酶（HDACs）通过调节转录因子的活性等影响成骨发育。

Histone modifications are implicated in influencing gene expression.

组蛋白修饰与影响基因表达有关.

Role of Histone Deacetylase 1 in Human Lung Adenocarcinoma Carcinogenesis

组蛋白去乙酰化酶1在肺腺癌发生发展中的作用

Design, Synthesis and Bioactivity Study of Novel Small-molecule Hydroxamates as Histone Deacetylases Inhibitors

以组蛋白去乙酰化酶为靶点的异羟肟酸类小分子抑制剂的设计、合成及生物活性研究

Expression of Histone Deacetylase 1 in Human Lung Cancer

组蛋白去乙酰化酶1在人肺癌组织中的表达

Cyclic tetrapeptide histone deacetylases inhibitor is one of effective types.

相对于其它种类的组蛋白去乙酰化酶抑制剂，环肽类组蛋白去乙酰化酶抑制剂对组蛋白去乙酰化酶表现出了高效的抑制作用。

The chromatin remodeling and histone acetylation were associated with transcription activation.

真核基因活化与染色质的重建及组蛋白的乙酰化相关.

Our data suggest that these histone modifications may act cooperatively to prepare chromatin for transcriptional activation.

我们的数据表明,这些组蛋白修饰可能共同作用于染色质的转录激活.

Objective: To investigate the influence of trichostatin A ( TSA), a histone deacetylase ( HDAC) inhibitor, on the growth of human bladder cancer cells and on the expression of related genes, and to explore the mechanism involved.

目的：观察组蛋白去乙酰化酶（HDAC）抑制剂曲古霉素A（TSA）对体外培养膀胱癌细胞生长情况及相关基因表达的影响，并探讨其可能的作用机制。

Therefore, this study aims to investigate the effect of histone deacetylase inhibitors on porcine granulosa cells and its preliminary mechanism. All the results can provide a reference for clinical use.

因此，本试验以TSA为代表药物，研究组蛋白去乙酰化酶抑制剂对猪卵巢颗粒细胞的作用，并就其机理作初步探讨，以为临床用药提供一定的参考。

This study was designed to improve the level of acetylation by knock down the expression of histone deacetylase expression with RNA interference technology. A possible mechanism was provided for improving epigenetic modifications and exploring the early development of mammalian embryos. 1.

本研究运用RNA干扰技术对小鼠HDAC2进行了干扰，通过抑制组蛋白去乙酰化酶的表达提高乙酰化修饰水平，以探索表观遗传修饰影响哺乳动物胚胎早期发育的可能机制。

Relationship Between Systemic Inflammation and Activity of Histone Deacetylase in Peripheral Blood Mononuclear Cells from COPD Patients

慢性阻塞性肺病外周血单个核细胞中的组蛋白去乙酰化酶活性与全身炎症的关系

Trichostatin A ( TSA), one of the inhibitors of HDACs, was used to determine the effects of core histone hyperacetylation on development ability and expression level of relational gene mRNA in different developmental embryos.

本实验通过一种组蛋白去乙酰化酶抑制剂TSA来诱导不同时期胚胎核心组蛋白高乙酰化，观察其对早期胚胎发育能力及相关基因mRNA表达水平变化的影响。

SATB 1 also globally regulates histone status in the chromatin by recruiting histone-modifying enzymes to the target-loci.

在染色体中,SATB1还在靶基因位置上通过复活组蛋白修饰酶普遍的调节组蛋白的状态.

The histone code will not be easy to crack.

看来,组织蛋白的密码不是那麽容易破解的.

Chicken liver chromatin component DNA : RNA : histone: non-histone ratio is 1∶0.

鸡肝染色质组成成分DNA∶RNA∶组蛋白∶非组蛋白的质量液度的比值为: 1∶0.

SET domain proteins contain conserved SET domains, which intensively involved in histone methylation.

SET蛋白是一类包含保守的SET结构域 、 与组蛋白甲基化密切相关的蛋白质.

The pharmacological actions histone deacetylase inhibitors and their potential clinical uses were reviewed.

综述了组蛋白去乙酰酶抑制剂的药理作用及其临床应用前景.

Arginine An AMINO ACID found especially in the histone proteins that surround DNA in chromosomes.

精氨酸:在染色体中与DNA非特异性结合的组蛋白中发现的一种氨基酸.

Z associates with functional regulatory elements, and CTCF marks boundaries of histone methylation domains.

Z和功能调控元件相关, CTCF标记组蛋白甲基化区域边界.

Screening the in Vitro Anti-tumor Activities of Novel Synthetics Targeting to Histone Deacetylases

靶向组蛋白去乙酰化酶新型化合物的体外抗肿瘤活性筛选

Dynamic Changes of Histone Deacetylase 1 during Regulated Growth of Bronchial Stem Cells in Human Bronchial Regeneration

组蛋白去乙酰化酶1在气管干细胞增殖分化过程中的时空表达

Moreover, HDAC inhibitor TSA induced histone hyperacetylation and stimulated Sp1 binding to mda-7 promoter, which in turn enhanced the expression of mda-7.

另外，组蛋白去乙酰化酶抑制剂TSA诱导组蛋白超乙酰化，促进Sp1与mda-7启动子结合，进而激活mda-7的表达。

In addition, histone exchange reveals new changing mechanism of DNA-histone interaction.

并且, 组蛋白替换揭示了DNA - 组蛋白相互作用变化的一种新的机制.

The level of histone acetylation plays an important role in progression, proliferation and differentiation of leukemia.

组蛋白乙酰化水平的异常在白血病的发展 、 增殖和分化中起着很重要的作用.

Histone deacetylase is protein that can influence the cell cycle, differentiation and apoptosis through the modification of acetyl level of histones.

组蛋白去乙酰化酶是一类通过调节组蛋白乙酰化的程度来影响细胞周期、分化和凋亡的蛋白。

Chromosome banding patterns are correlated with unique patterns of histone modifications.

染色体带型和组蛋白修饰的特有模式相关。

Typical patterns of histone methylations exhibited at promoters , insulators, enhancers, and transcribed regions are identified.

表现在启动子、绝缘子 、 增强子和转录区域的组蛋白甲基化的典型模式被确定.