histone modification

Epigenetics refers to gene expression changes which DNA sequence will not changed, the main contents of epigenetic mechanism is that DNA methylation and histone modification.

表观遗传学指不发生DNA序列改变的基因表达改变，DNA甲基化和组蛋白修饰是其中的两个主要内容。

Histone modifications plays an important role in transcriptional regulation. Histone modification enzymes, such as HATs, HDACs, HMTs control the chromatin structure and gene expression, thus participate in gene transcription regulation of specific sites.

组蛋白修饰在基因转录调控中占有重要地位，在组蛋白修饰酶HATs、HDACs、HMTs的共同作用下控制着染色质的结构和基因的表达，从而参与特定位点的基因转录调控。

Epigenetic mechanisms, including DNA methylation, histone modification and chromatin remodeling, have been demonstrated to be involved in the development of SLE.

表观遗传学涉及的机制主要包括DNA甲基化和组蛋白修饰及染色质重塑。

DNA hypomethylation, likely to be cooperating with aberrant histone modification, may induce the activation of some T cell genes and development of autoimmunity in SLE.

DNA的低甲基化可能在异常组蛋白修饰的协同下引起某些T细胞基因的异常活化，导致狼疮自身免疫的发生。

The recent study confirmed that the level of DNA methylation in genome was not only affected by DNA methyltransferase ( DNMT), but also by other factors, such as histone modification, diet and environment and RNA interference, etc.

目前研究发现，基因组中DNA甲基化的水平不仅受DNA甲基化转移酶（DNMT）的影响，还与组蛋白甲基化、饮食与环境、RNA干扰等多种因素有关。

DNA methylation is often interact with histone modification to regulate gene expression.

DNA甲基化往往与组蛋白修饰相互作用共同调控基因的表达。

The relationship between histone acetylation modification and IFN-gamma responsive gene regulation

组蛋白修饰与干扰素γ应答基因调控的关系

Objective To study the role of histone modification in the regulation of IFN-gamma-activated gene using chromatin immunoprecipitation technique.

目的应用染色质免疫沉淀技术研究组蛋白修饰与干扰素γ应答基因调控的关系。

Epigenetic variation plays an important role in plant growth and development, including DNA methylation, histone modification, chromosome remodeling, and RNA interference and so on.

表观遗传变异对于植物的生长发育起着重要作用，主要包括DNA甲基化、组蛋白修饰、染色体重塑和RNA干涉等。

AIMNESS: Histone modification as one of the key epigenetic regulation mechanisms plays critical roles in various biological processes, including regulation of chromatin structure dynamics and gene expression.

目的：组蛋白修饰在基因表达调控等多种生物学过程中起着重要作用，是表观遗传中重要的调控机制之一。

DNA methylation catalyzed by DNA methyltransferases interacts with histone modification to inhibit gene transcription, induce gene silencing at the participation of many regulators.

DNA甲基化由DNA甲基转移酶催化，在多种调节因子的参与下，与组蛋白修饰相互作用，抑制基因转录，导致基因沉默。

Based on those disadvantages of traditional methods, the study for DNA demethylation and the relationship between DNA methylation and histone modification are difficult.

因此，也就为研究DNA去甲基化以及DNA甲基化与组蛋白修饰之间的关系造成了麻烦。

Aberrant DNA Methylation and Histone Modification in Tumor

肿瘤DNA异常甲基化与组蛋白修饰

The changes of epigenetics such as DNA methylation and histone modification can regulate the expression of genes and play an important role in the development of tumors.

表遗传学改变，如DNA甲基化和组蛋白修饰改变可以调节基因的表达，在肿瘤的发生和发展中可能起关键作用。

Epigenetic modification includes DNA methylation and histone modifications.

表观遗传修饰主要有DNA甲基化和以组蛋白修饰为特征的染色质重塑。

Core processes of epigenetic inheritance include DNA methylation, histone modification, nucleosome remodeling, nuclear dynamics and chromatin interaction with non-coding RNAs.

核心过程的表观遗传的产业包括DNA甲基化、组蛋白改性、核小体重建、核染色质动力学和互动子都存在。

Differential histone modification marks of active versus repressed genes accompany these DNA methylation changes.

活化的差异组蛋白修饰标记物对抑制基因的改变伴随着这些DNA甲基化改变。

The Effect of DNA Methylation and Histone Modification on the Development of Cloned Embryos

DNA甲基化与组蛋白修饰对克隆胚发育的影响

The two primary changes of epigenetic mechanism are the DNA methylation and the histone modification.

表观遗传改变的两个最主要机制就是DNA甲基化和组蛋白修饰。

Non-DNA sequence variations, such as DNA methylation and histone modification, can also change biological traits such as plant height, flowering time, resistance and yield.

非DNA序列变异，如DNA甲基化、组蛋白修饰等亦可改变生物性状，包括重要农艺性状如株高、花期、抗性、产量等，并可稳定遗传。