integrase

hiv-1 integrase ( in) integrates viral dna into host cells through two steps metal ions-dependent reactions.

HIV-1整合酶（IN）通过依赖金属离子的两步反应将病毒DNA整合入宿主细胞中。

Methods To detect the gene of class ⅰ integrase by PCR with universal primer and conjugal transfer the plasmid of class ⅰ integron positive strains.

方法用I类整合酶基因通用引物对临床分离大肠埃希菌进行PCR检测，并对阳性菌株进行接合转移实验。

Screening and structural analysis of integrase genes in gram-negative bacteria The distribution of class ⅰ integron in ESBLs and Study on resistant genotypes of ESBLs

临床分离的革兰阴性菌3类整合酶基因的筛查与Ⅰ类整合子结构分析产ESBLs菌株Ⅰ类整合子分布与耐药基因的研究

The Research Status of Integrase Inhibitors for Human Immunodeficiency Virus

人免疫缺陷病毒整合酶抑制剂的研究现状

However, lack of complete IN structure and the limitation of its screening method for inhibitors in vitro, blocked the development of drug design based on receptor. So far, only one compound as integrase inhibitors has been used in clinical treatment.

但由于HIV-1IN的全酶结构未知以及受体外筛选实验的限制，使得基于受体结构的药物设计进展缓慢，目前仅有一个化合物作为整合酶抑制剂用于临床治疗。

Integrase is one of the three enzymes of the irus that is required for iral replication.

整合酶是病毒复制所需要的三种酶之一.

Terphenyllin has not been extensively studied but has been reported to exhibit anti-oxidative activity, acts as a plant growth inhibitor and shows weak activity against HIV integrase.

三联苯曲菌素还没有被广泛的研究但已报道显示其有抗氧化的活性，做为一种植物生长抑制剂，也显示了弱的抗HIV整合酶的活性。

Rational design of HIV-1 integrase inhibitors using a de novo drug design method

用从头药物设计方法合理设计HIV-1整合酶抑制剂

HIV-1 integrase ( IN ) integrates viral DNA into host cells through two steps metal ions-dependent reactions.

HIV -1 整合酶 ( IN ) 通过依赖金属离子的两步反应将病毒DNA整合入宿主细胞中.

raltegravir, sold under the trade name isentress, is a 'first-in-class' hiv integrase inhibitor.

在美国以商标名称Isentress出售的新药，是最新HIV病毒抑制剂。

IntI 1 integrase gene and class 1 integron marker genes were detected by PCR.

PCR扩增检测intI1整合酶基因,sul1和qacE△1基因.

Chemical Biology Directed Discovery and Structural Optimization of HIV-1 Integrase Inhibitors

化学生物学导向的HIV-1整合酶抑制剂的发现和结构优化

The positive ratio of class 1 integrase relative genes sul 1 and qacE △ 1 was 94% ( 45/ 48) and 90% ( 43/ 48) respectively.

1类整合子相关的sul1和qacE△1基因的阳性率分别为94%（45/48）和90%（43/48）。