irreversibly

Exemestane is a third-generation steroidal aromatase inhibitor which can cause inactivation of aromatase enzyme by binding irreversibly to the substrate binding site and can be used to treat advanced breast cancer in postmenopausal women.

依西美坦为第三代甾体类芳香化酶抑制剂，临床上治疗绝经后妇女晚期乳腺癌，作用机制为与芳香化酶底物结合位点不可逆结合使芳香化酶失活。

To cause to lose ( energy, such as heat ) irreversibly.

消耗,使耗散不可逆地失去 ( 能量, 如热 )

On Au ( 111) surface, the irreversibly adsorbed dense and disordered SbO~ (+) film structure remains after reduction of the film;

在Au（111）表面，致密无序膜的SbO+不可逆吸附层还原后基本保持原有的无序结构；

Pyrrole and Benzaldehyde react with acid catalysis to form the cyclic intermediate 3 ( Tetraphenylporphyrinogen). 3 is converted irreversibly to the TPPH_2 and TPC.

吡咯、苯甲醛在酸催化下生成环状中间体，不可逆的转化生成TPPH2与TPC；

Even under this optimistic scenario, however, the world will have changed irreversibly.

但即使在这种乐观情况下, 世界也将发生不可逆转的变化.

The structured substances of life produce, develop and evolve irreversibly in the non-symmetry in the direction of the time vector.

生命的结构物质，在不对称中，在时间箭头的方向上不可逆地产生着、发展着、演化着。

However, along with the change of times and social system and the flow of the population, the function of ancestral halls has irreversibly changed. Now the protection of the ancestral temples is not optimistic.

但是随着时代的更迭、社会制度的变化、人口的流动，祠堂的功能性质发生了不可逆转的变化，使得现在祠堂建筑的保护情况并不乐观。

Television has irreversibly changed our perception of the Royal Family.

电视不可逆转地改变了我们对皇室的印象。