keratoderma

Five cases of spiny keratoderma are reported.

报告5例多发性棘状角皮症。

Results The patient was a 3-year-old girl who presented increased skin fragility with trauma-induced, blisters and erosions, combined with short and sparse hair, finger-and toe-nail dystrophy and palmoplantar keratoderma.

结果先证者为3岁女孩，主要表现为皮肤脆性增加，受力部位易出现水疱及糜烂，并伴有头发短、稀，甲营养不良和掌跖角化等外胚层发育不良的表现。

Towards characterization of palmoplantar keratoderma caused by gain-of-function mutation in loricrin: Analysis of a family and review of the literature

兜甲蛋白功能获得性突变引发的掌跖角化病的特征：家系分析和文献回顾

But hydrophilia macromolecule drug like DNA vaccine can not penetrate the keratoderma and enzyme system in skin will degrade DNA vaccine so that antigen presenting cell can not catch DNA vaccine.

然而DNA疫苗这样的亲水性大分子药物是无法穿透皮肤角质层的屏障，并且皮肤内的酶系会对DNA疫苗产生降解作用，而使抗原提呈细胞无法捕获DNA疫苗。

Objective To identify mutations of keratin 9 ( KRT9) gene in a big Chinese family with epidermolytic palmoplantar keratoderma ( EPPK) combined with knuckle pad like lesions and nail lesions.

目的明确一个伴随有类似关节指垫样病损和指甲病变的表皮松解性掌跖角化病的中国家系中角蛋白9（keratin9，KRT9）基因突变情况。

A case of epidermolytic palmoplantar keratoderma is reported.

报告1例表皮松解性掌跖角化病。

Objective To characterize the clinical and genetic features of punctate palmoplantar keratoderma ( PPK) in 40 cases from 5 Chinese Han families.

目的了解中国汉族人点状掌跖角化病（punctate，palmoplantar keratoderma）的临床表型和遗传学特点。

Objective To investigate the keratin 9 gene mutation in epidermolytic palmoplantar keratoderma ( EPPK) and its relationship with clinical manifestations.

目的探讨表皮松解性掌跖角化症家系的KRT9基因突变与临床表现的关系。

Focal palmoplantar keratoderma caused by an autosomal dominant inherited mutation in the desmoglein 1 gene

常染色体显性遗传性桥粒芯糖蛋白1基因突变引起的局限性掌跖角化病

Conclusion The high-speed dermabrasion is best for the typical ephelides, senile keratoderma blennorrhagicum 、 radiative pigmentation 、 pigmented spots on superfacial scars and grafted skins, which could not be used for untypical ephelides and liver spots.

结论：微创高速磨削术治疗皮肤色素性病变的最佳适应证为典型雀斑、老年斑、放疗性色素沉着、表浅瘢痕色斑和移植皮片色斑，禁忌证为不典型雀斑和黄褐斑。

Results PmTe can effectively increase the moisture of keratoderma, decrease the lipofuscin in keratinized cell.

结果何首乌提取物能有效提高皮肤角质层水分含量，降低角质细胞脂褐素含量。

Mutation analysis of keratin 9 gene in a pedigree with epidermolytic palmoplantar keratoderma

一个表皮松解性掌跖角化病家系的KRT9基因突变分析

Hotspot of the mutations of keratin 9 gene in a diffuse palmoplantar keratoderma family

弥漫性掌跖角化病家系角蛋白9基因突变热点区的检测

Clinical and Genetic Features of Punctate Palmoplantar Keratoderma in 40 Cases from 5 Chinese Han Families

中国汉族人5家系40例点状掌跖角化病临床及遗传特点分析

Screening and Analysis of Keratin 9 Gene ( KRT9) Mutation in 4 Chinese Families with Epidermolytic Palmoplantar Keratoderma

4个中国人表皮松解性掌跖角化症家系KRT9基因突变的研究