Objective A hepatitis B immunogenic complex therapeutic vaccine, yeast-derived recombinant HBsAg combined with human anti-HBs immunoglobulin ( YIC), was evaluated for safety and immune response in phase ⅰ clinical trial.
目的观察治疗性乙型肝炎(乙肝)疫苗(重组乙肝表面抗原和高效价抗乙肝免疫球蛋白组成的免疫复合物,简称乙肝疫苗)Ⅰ期临床研究中诱生的免疫应答作用。
Anti HBs alone was detected in 20.0% of hepatitis workers, significantly higher than that foundin the persons in the other four groups ( 0~ 6.3%) ( P0.025).
肝炎研究者单纯抗-HBs流行率高于其他四组(P0.025)。
Standardized positive rate of anti-HBs in female ( 81.12 % ) was higher than that in male ( 65.30 % ) ( P < 0.01 )
标化 抗 -HBs阳转率女性为81.12%,男性为 65.30% ( P<0.01 ).
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