STZ is one of the classic diabetes inducers, characterized by selectively and directly impairing DNA of β cell which caused by its alive hydrocarbyl; then the antigen of β cell released which consequently processed and presented to T lymphocyte by macrophage.
STZ是经典的致糖尿病药物,具有活泼的烃基结构,可以选择性地直接损伤胰岛β细胞DNA,使β细胞抗原释出并被巨噬细胞加工、呈递给T淋巴细胞,引起免疫应答反应;
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