Maturation of presynaptic transmitter secretion machinery and trafficking of postsynaptic receptors are two critical steps in synaptogenesis and synaptic development of central nervous system ( CNS).
突触前递质释放装置的发育成熟和突触后受体的转运是中枢神经系统突触发育过程中非常重要的两个方面。
Multiple protein components at the active zone region interact and coordinate with each other to control and regulate docking, priming and fusion of the synaptic vesicles with presynaptic membrane, and to further maintain the normal transmitter release process.
活动区内多种蛋白组分相互作用与相互协同而严格调控突触囊泡在突触前膜的入坞、触发与膜融合等过程,以保证正常递质释放过程的完成。
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