分子损害
This review concentrates on drug-resistance mechanisms of taxanes that include drug target change, avidity change between drug-target interaction, decrease of cellular effective drug concentration, downstream cellular responses to a drug target molecular lesion, and cell cycle regulation-mediated drug resistance.
该文作者就其耐药机制的研究进展,分别从药物靶点及靶点与药物的亲和力改变、细胞内有效药物浓度降低、药物靶分子下游效应信号途径异常、细胞周期调控等方面作如下综述。
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