overexpression

Objective Construction of transgenic mice with selective brain overexpression of Kynureninase ( Kynu) to investigate the effect of increased KYNU activity on blood pressure ( BP).

目的本研究旨在构建脑组织选择性过表达犬尿氨酸酶（Kynu）的转基因小鼠，在整体水平研究KYNU活性增强对血压的影响。

Overexpression of c-Src leads to tyrosine phosphorylation and cell transformation of many kinds of protein substrates.

过表达 Src 可以导致多种蛋白质底物的酪氨酸磷酸化以及细胞转化.

It has been proved that the main but not the only causes for the drug resistance of RCC are the overexpression of P-glycoprotein ( P-gp) and the activity increase of Glutathione ( GSH)-dependent detoxication enzyme system.

目前研究证实P-糖蛋白（P-gp）过度表达以及谷胱甘肽依赖性解毒酶系统活性增高在介导肾癌对化疗药物的耐受过程中发挥了重要作用，但上述因素并非是化疗药物耐药的唯一途径。

In contrast, overexpression of dpr 2 causes developmental defects in midline mesodermal tissues a phenotype resembling oep.

与此相反, 在胚胎中过量表达dpr2,可以导致胚胎中线中胚层组织发育缺陷,引起类似oep的表型.

Cell cycles were blocked in G1 stage. Conclusion Overexpression of PTEN will induce G1 arrest in rar renal fibroblast cells, which associated with the nuclear location of PTEN.

结论PTEN过度表达将引起肾脏成纤维细胞周期G1期阻滞，这一过程与PTEN在细胞核定位有关。

These results demonstrate that overexpression of COX-2 can lead to phenotypic changes that alter the metastatic and angiogenic potential of TCC cancer cells.

结论：COX-2的过表达能促进EJ肿瘤细胞侵袭转移和血管生成能力表型方面的改变，即COX-2能促进肿瘤细胞体外侵袭能力的增强和促血管生成能力的增强。

Overexpression of ILK in HKC tansfered with pCMV-wtILK could induce FN expression.

转染pCMV-wtILK质粒的HKC细胞,其FN的表达呈增加趋势.

Conclusion Attenuation of AGEs-induced TGF-β_1 and CTGF mRNA overexpression in renal fibroblasts through scavenging of free radical and inhibition of oxidative stress may be one of mechanisms underlying EGb in prevention and therapy of DN.

结论银杏叶提取物可能通过清除自由基，抑制氧化应激反应而拮抗肾间质成纤维细胞中AGEs诱导的TGF-β1和CTGF mRNA过表达，可能是EGb防治DN的作用机制之一。

Construction and appreciation of p50 gene cells stable overexpression

稳定过表达p50基因细胞株的构建及鉴定

C ras overexpression was associated with tumor differentiation.

高分化组的C-ras基因过度表达率显著高于低分化组.

Conclusions: 1 There is overexpression of COX-2 in PC-3 m cell line as in PC-3 cell line.

结论: l同PC上细胞系一样,PC上m细胞系中存在 COX1mRNA 及蛋白质表达.

Treatment with F_2 before hypoxia and reoxygenation significantly attenuated the cardiomyocytes injury and inhibited the overexpression of Egr-1 after H/ R.

缺氧及复氧前给予F2则能改善H/R所致心肌细胞病理损害，抑制心肌细胞Egr-1的过量表达。

Conclusions-Cardiac-specific overexpression of A 20 improves cardiac and inhibits cardiac and fibrosis after acute myocardial infarction.

结论:心脏特异型过表达A20改善心脏功能,抑制急型心肌梗死后的心脏重建、凋亡、炎症和间质纤维化.

Cloning and overexpression of rat ovary LH/ hcg receptor cDNA in insect cells

大鼠卵巢促黄体激素/人绒毛膜促性腺激素受体cDNA的克隆和在昆虫细胞中的高效表达

Clone and Overexpression of a Novel Thermostable Glucan Phosphorylase from a Thermophilic Bacterium

一种高温细菌葡聚糖磷酸化酶基因的克隆与表达

Moreover, the overexpression of TALL 1 in transgenic mice can result in severe B cell hyperplasia and autoimmune lupus like disease.

另外，TALL1在转基因鼠中的过量表达可引起严重的B细胞增生以及与狼疮有关的自身免疫性疾病。

Cells to trigger an adaptive response to hypoxia conditions that result in hypoxia-inducible factor ( HIF ) overexpression.

缺氧使细胞触发适应性反应导致缺氧诱导因子 ( HIF ) 过度表达.

Overexpression of ICAM-1 and reduced expression of E-CD were associated with low-grade.

ICAM-1、E-CD的表达异常与病理学分级有关。

Overexpression of bcl-2 gene was found in all cases; 1 of 11 cases had t ( 14,18) ( q32, q21) translations.

我们应用免疫组化染色和聚合酶链反应检测了11例慢性淋巴细胞白血病bcl-2基因表达和重排，结果发现所有病例均高度表达Bcl-2蛋白，1例有t（14,18）（q32，q21）染色体易位。

Conclusions The overexpression of MMP 2 and MMP 9 may be correlated with the remodelling of blood tumor barrier in human brain glioma.

结论MMP-2、MMP-9与人脑胶质瘤侵袭微生态系统中血瘤屏障的改造重建有关。

Conclusion There is mutant-type p53 and MDM2 protein overexpression in NHL. The p53 gene inactivation resulting from MDM2 protein over expression and/ or p53 gene mutation may play all important role in NHL.

结论p53和MDM2蛋白在NHL病理组织中均呈高表达，MDM2蛋白和/或p53基因突变使p53基因功能失活在NHL发生中可能有重要作用。

Conclusion: p53 mutation and p53 protein overexpression play important roles in the occurrence and development of oral tongue squamous cell carcinoma.

结论：p53基因突变及其蛋白过量表达与口腔舌鳞癌的发生、发展密切相关。

[ Conclusions] The A549/ TXL20 cell line shows drug resistant phenotype and may be related to overexpression of DNA pol β.

结论A549/TXL20具有多药耐药表型，耐药性产生可能与细胞内DNA polβ表达增高有关。

Overexpression of Egr-1 promotes epithelial-to-mesenchymal transition on renal tubular epithelial cells

早期生长反应因子1过表达促进肾小管上皮细胞转分化

P gp and LRP sometimes had co overexpression in glioma tissues.

Pgp和LRP在人脑胶质瘤中有共同表达.

It is interesting that overexpression of LeZE enhances the sensitivity of tomato PSII photoinhibition to high light and chilling stress. However, the depletion of LeZE was helpful in alleviating the photoinhibition of tomato plants under low temperature and affected the colour of tomato mature flowers.

过量表达该基因可增强番茄植株对光抑制的敏感性，而抑制该基因表达可减轻番茄植株在低温弱光胁迫下的光抑制程度，影响番茄花的颜色。

Conclusion STK 15 protein overexpression may be a novel marker for diagnosing tumor differentiation of colorectal cancer.

结论STK15蛋白过表达程度可望作为判定结肠癌分化程度的新指标.

Conclusions : Overexpression of cyclin D 1 and CDK 4 may involve in the onco-pathogenesis of ESC.

我们在相应的癌旁组织中亦发现cyclinD1和CDK4的过表达.

Also, overexpression of p18~ ( INK4C) in K562 cells resulted in G0/ G1 arrest and partial erythroid differentiation.

在K562细胞中过表达p18~（INK4C）基因可诱导细胞G0/G1期阻滞和部分红系分化。

Research indicated that overexpression of HER-2 had significantly positive correlation with microvessel density ( MVD) in tumor tissue, and activated HER-2 could up-regulate angiogenesis through signal pathways.

研究显示HER-2过表达与肿瘤组织内微血管密度明显相关，HER-2激活后可通过多种信号通路来调控血管生成。