senile plaques

Human apoE 4 has been found in senile plaques ( SPs ) and neurofibrillary tangles ( NTFs ) in AD brains.

研究进一步表明,AD患者脑内的老年斑和神经原纤维缠结中存在有较多的载脂蛋白E4 ( apolipoproteinE4, apoE4 ).

In Non-gmo models most only simulate a certain aspect of AD pathology characteristics, while the pathological process of AD is complex, various, and do not present the AD typical characteristic in the brain: senile plaques ( SP) and neurofibrillary tangles ( NFTs).

非转基因模型中，大部分模型只针对AD病理特征的某一个方面，而AD的病理过程是复杂的多方面的，且不呈现AD脑内特征性改变：SP和NFTs。

Hippocampal ( hippocampus, dentate gyrus) have part of the nerve cell nucleus condensation and degeneration, white matter loose edema, and a large number of senile plaques formed.

海马结构（海马、齿状回）部分神经细胞核固缩、变性伴胶质细胞增生，白质疏松水肿，大量老年斑形成。

Some scholars believe that c1q plays a toxic effect in AD: c1q can combine with A beta peptide and promote the nucleation process of senile plaques.

部分学者认为clq在AD发病中起着毒性作用：clq通过与Ap多价结合，促进老年斑的成核过程。