simvastatin

OBJECTIVE To prepare sustained-release dropping pills of Simvastatin and optimize its preparation technology.

目的制备辛伐他汀缓释滴丸并优化其制备工艺.

CONCLUSION Early Simvastatin treatment effectively improves the cardiac function in ACS patients in a dose-dependent manner.

结论早期大剂量辛伐他汀干预能安全有效地改善ACS患者的心功能,降低心律失常的发生率,且呈剂量依赖性.

Effects of simvastatin on proliferation, apoptosis and caspase-3 expression of rat mesangial cell

辛伐他汀对大鼠系膜细胞增殖、凋亡及细胞内半胱氨酸天冬氨酸蛋白酶3表达的影响

Indeed, as we wrote here and here, Lipitor is already hurting because of competition from simvastatin, the generic version of Merck's Zocor.

实际上，立普妥销售已经由于默克公司降胆固醇药舒降之的仿制药塞瓦停的竞争而受损。

Role of simvastatin on the proliferation and migration of rat adventitial fibroblasts

辛伐他汀对大鼠血管外膜成纤维细胞增殖迁移和胶原合成的影响

Effect observation of simvastatin treatment for children with kidney disease syndrome

辛伐他汀治疗小儿原发性肾病综合征的疗效观察

Objective To investigate the influences of simvastatin on carotid artery Intima-media thickness ( IMT ) and carotid atherosclerotic plaque.

目的探讨辛伐他汀对颈动脉内膜-中膜厚度及颈动脉粥样硬化斑块的影响.

Effect of Zocor Simvastatin on Nitric Oxide and Endothelin in Kidney Damaged Rats Induced by Hyperlipidemia

舒降之对高脂血症肾损害大鼠一氧化氮和内皮素水平的影响

Effect of simvastatin on angiogenesis of ischemic myocardium in myocardial infarcted rats

辛伐他汀对心肌梗死大鼠缺血心肌毛细血管新生的影响

Conclusion The simvastatin with omega-3 fatty acids is safe and effective in treatment CHD and CHD risk equivalent patients with mixed dyslipidemia.

结论辛伐他汀加用国产omega-3脂肪酸调脂治疗冠心病及其等危症合并混合性血脂异常患者安全、有效。

High-dose atorvastatin vs usual-dose simvastatin for secondary prevention after myocardial infarction: The IDEAL study: A randomized controlled trial

一项比较大剂量阿托伐他汀与常规剂量辛伐他汀用于心肌梗死二级预防的随机对照试验：IDEAL研究

Objective: To evaluate the effects of simvastatin plus omega-3 fatty acids on HsCRP ( high sensitive C-reactive protein), blood lipids and fibrinolysis in patients with mixed dyslipidemia.

目的：评价辛伐他汀加用Omega-3脂肪酸对冠心病及冠心病等危症合并混合性血脂异常患者高敏C反应蛋白（HsCRP）、血脂及纤溶的影响。

On the one hand, a large number of clinical trial results showed that simvastatin can significantly reduce cardiovascular disease or coronary heart disease incidence and mortality. On the other hand, and its toxic side effects and drug tolerance is good.

辛伐他汀能够显著降低心血管疾病或冠心病的发病率和死亡率，其毒副作用小，药物耐受性好，是降低体内胆固醇的首选药物之一。

Effect of simvastatin on non-neuronal M cholinoceptor of rabbit aorta endothelium with hyperlipemia

辛伐他汀对高脂血症兔主动脉内皮细胞非神经性M受体的影响

Simvastatin is sold as a single-ingredient generic medication and as the brand-name Zocor.

美国市场上含辛伐他汀的药品有单一成分的辛伐他汀仿制药及商品名药舒降之。

Methods: Simvastatin was synthesized from lovastatin via acetylization, methylation, hydrolytic decomposition and cyclization reactions.

方法: 以洛伐他汀为原料,通过酰化 、 甲基化 、 水解、环合等反应合成了辛伐他汀.

Both simvastatin and CDPC can relieve the damages of the brain in rats HIBD.

辛伐他汀和胞二磷胆碱可减轻新生大鼠HIBD后脑组织损害.

Efficiency and safety of high dose Simvastatin in elderly patients

长期大剂量辛伐他汀对高龄患者疗效及安全性的评价

Simvastatin may effectively attenuate DN progression through down-regulating the expression of TGF-� � via p 38 MAPK.

斯伐他汀可能通过抑制p38MAPK磷酸化而减少TGF - β的蛋白表达.

Comparison of Clinical Efficacy of Rosuvastatin versus Simvastatin for Hyperlipidemia in Elderly Patients

瑞舒伐他汀与辛伐他汀治疗高龄患者高血脂的临床疗效比较

Objective To investigate the effect of Simvastatin on function of osteoblastic cell differentiation of human bone marrow stromal cells ( hMSCs) in vitro, and to study the mechanisms of anabolic effect of Simvastatin on bone formation.

目的观察辛伐他汀对体外培养的人骨髓基质干细胞（human bone marrow stromal cells，hMSCs）成骨分化功能的影响，探讨其刺激成骨的作用机制。

Simvastatin and atorvastatin influence on serum MDA, SOD in rats with focal cerebral ischemia-reperfusion injury

辛伐他汀、阿托伐他汀对脑缺血再灌注大鼠血清MDA、SOD的影响

Randomized double-blind placebo controlled study of simvastatin with omega-3 fatty acids in the treatment of coronary heart disease ( CHD) and CHD risk equivalent patients with mixed dyslipidemia

辛伐他汀加omega-3脂肪酸治疗冠心病及其等危症合并混合性血脂异常随机双盲对照研究

A good safety was observed after long time application of simvastatin.

该药长期应用具有良好的安全性。

After three-week treatment with simvastatin, serum IL-6, hs-CRP, total cholesterol ( TC) and low density lipoprotein cholesterol ( LDLC) levels decreased significantly in the simvastatin group ( P < 0.001), but not in the routine group.

治疗3周后，辛伐他汀组血清白细胞介素6、高敏C反应蛋白、总胆固醇和低密度脂蛋白胆固醇浓度明显下降（P<0.001）；

Experimental study of abating oxidative damage after acute myocardium infarction by Simvastatin

辛伐他汀抑制急性心肌梗死后心肌氧化损伤的实验研究

Results The XRP is the same as simvastatin can evidently reduce TC and TG content, middle XRP dose and high XRP dose group can markedly boost up HDL-C level.

结果血管软化丸和舒降之一样能显著降低大鼠血清总胆固醇、甘油三酯，中、高两个剂量可明显升高大鼠高密度脂蛋白胆固醇含量。

Objective: To compare the therapeutic effects of Huzhang tablets ( HZT) and simvastatin tablets ( SIT) in the treatment of hyperlipemia.

目的：比较虎杖片与辛伐他汀治疗高脂血症的疗效。

Effects of Zocor Simvastatin on Tumor Necrosis Factor-alpha and Malondialdehyde in Rats with Renal Injury Induced by Hyperlipidemia

辛伐他汀对高脂血症肾损害大鼠的保护作用

Objective To study the effect of simvastatin on the expression of bone morphogenetic protein 2 ( BMP 2) and alkaline phosphates ( ALP) activity in the primary cultured bone marrow stromal cells, and to elucidate the mechanism of the anabolic osteogenetic effect of simvastatin.

目的研究辛伐他汀对原代培养的骨髓基质细胞骨形成蛋白-2（BMP-2）表达及碱性磷酸酶活性的影响，探讨其刺激成骨的作用机制。