trifluoroacetic

Friedel-Crafts Acylation Reactions Catalyzed by Trifluoroacetic Anhydride-Synthesis of 4-Ethyl-2,5-dimethoxyphenyl Alkyl Ketones

三氟乙酸酐催化的Friedel-Crafts酰化反应&4-乙基-2,5-二甲氧基苯基烷基酮的合成

Trifluoroacetic acid ( TFA) was used as the retaining acid and ammonia liquor as the eluent base. The solvent system was n-hexane-acetic ester-methanol-water ( ratio by volume was 9 ∶ 1 ∶ 5 ∶ 5).

采用三氟乙酸做为保留酸，氨水作为洗脱碱，溶剂系统为正己烷/乙酸乙酯/甲醇/水（体积比为9∶1∶5∶5）。

Methods 3-Fluoro-4-methoxybenzaldehyde was prepared through the reaction of 2-fluoroanisole with hexamethylenetetramine in the presence of trifluoroacetic acid, and then extracted with anhydrous ether from the mixture after basification with potassium carbonate.

方法以三氟乙酸为溶剂，邻氟苯甲醚与六次甲基四胺发生回流反应，通过无水碳酸钾调节酸碱度、无水乙醚萃取等操作制备3氟4甲氧基苯甲醛。