殚精竭虑

The Ptolemys were an originally Macedonian family who ruled Egypt after Alexander the Great died. They reigned for almost 300 years, and kept their bloodlines as "pure" as could be.

托勒密王族（Ptolemys）是马其顿帝国的原住家族，他们在亚历山大大帝（Alexander the Great）死后统治埃及近300年。其间，为保护家族血统的“纯粹性”，他们可谓“殚精竭虑、极尽所能”。

Effort is the gist of it.

殚精竭虑就是全力以赴的精要所在.

The HSBC case has renewed hopes that the fight against organised crime can be won using "Ninja accountants" who will drain its lifeblood with spreadsheets as happened to Al Capone, who was imprisoned on tax evasion charges.

汇丰案件使人们重燃希望：打击有组织犯罪可以借助为电子表格殚精竭虑的“忍者会计师”获胜正如因被控逃税而入狱的阿尔卡彭（a.capone）的遭遇那样。

Therefore, I advise you to stand on ceremony before anyone else and take pains not to do anything against etiquette lest you give offences or make enemies.

寄语读者，切记谦恭待人，殚精竭虑，勿违礼仪，以免出言冒犯，招致仇敌。

Taking too much care of Hillarycare.

为“希拉里医改”殚精竭虑.

so " money" problem forced many rural teachers rack one's brains, thus further huafa early, prematurely senile.

于是“钱”的问题逼迫着很多农村教师殚精竭虑，从而进一步华发早生，未老先衰。